Tubulin isotype specificity in neuronal migration: Tuba8 can’t fill in for Tuba1a
نویسنده
چکیده
Several tubulin isotypes, including Tuba1a, are associated with brain malformations. In this issue, Belvindrah et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607074) show that Tuba1a and Tuba8 differentially regulate microtubule organization in neurons, and they provide insights into the mechanisms by which Tuba1a mutations disrupt adult mouse brain morphology.
منابع مشابه
Jcb_201705172 1..3
1 The Rockefeller University Press J. Cell Biol. https://doi.org/10.1083/jcb.201705172 Microtubules regulate essential cellular events, such as cell migration, morphological changes, and cell division. Microtubules consist of laterally connected protofilaments that are constructed from polymerized αand β-tubulin heterodimers. To date, at least eight αand nine β-tubulin isotypes have been identi...
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Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled from α/β-tubulin heterodimers. Mutation of the α-tubulin isotype TUBA1A is associated with cortical malformations in humans. In this study, we provide detailed in vivo and in vitro analyses of Tuba1a mutants. In mice carrying a Tuba1a missense muta...
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A spectrum of neurological disorders characterized by abnormal neuronal migration, differentiation, and axon guidance and maintenance have recently been attributed to missense and splice-site mutations in the genes that encode α-tubulin and β-tubulin isotypes TUBA1A, TUBA8, TUBB2B, and TUBB3, all of which putatively coassemble into neuronal microtubules. The resulting nervous system malformatio...
متن کاملDistinct α- and β-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the ‘multi-tubulin’ hypothesis
Synopsis The many functions of the microtubule cytoskeleton are essential for shaping the development and maintaining the operation of the nervous system. With the recent discovery of congenital neurological disorders that result from mutations in genes that encode different αand β-tubulin isotypes (TUBA1A, TUBB2B, TUBA8 and TUBB3), scientists have a novel paradigm to assess how select perturba...
متن کاملMutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia.
The critical importance of cytoskeletal function for correct neuronal migration during development of the cerebral cortex has been underscored by the identities of germline mutations underlying a number of human neurodevelopmental disorders. The proteins affected include TUBA1A, a major alpha-tubulin isoform, and microtubule-associated components such as doublecortin, and LIS1. Mutations in the...
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عنوان ژورنال:
دوره 216 شماره
صفحات -
تاریخ انتشار 2017